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Article

Osmotic conditions shape fitness gains and resistance mechanisms during E. coli and T4 phage co-evolution.

mBio - 9 Sept 2026

Hunter Michael, Lyall Eric, Verma Kriti, Tropini Carolina

Abstract excerpt

Environmental conditions strongly influence interactions between bacteria and bacteriophages (phages). Here, we examined how osmolality (solute concentration) shapes the in vitro co-evolution of T4 phage and its host Escherichia coli during serial passage. When evolved independently, we observed substantial fitness gains in both bacteria and phages, particularly in high-osmotic conditions. During co-evolution,...

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Topics

Escherichia coli
Bacteriophage T4
Osmolar Concentration
Genetic Fitness
Mutation
Virulence
Osmotic Pressure

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Identifiers

PMID: 42606218
DOI: 10.1128/mbio.01167-25
PMCID: PMC13559767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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