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Article

Single-Particle Tracking and Positional Phenotyping Reveal Variant-Specific Early Checkpoints in SARS-CoV-2 Cell Entry.

ACS applied bio materials - 17 Aug 2026

Schulz Frank H, Dreisler Marcus W, Koylyu Denis, Valero Julián, Malle Mette Galsgaard, Civit Laia, Kjems Jørgen, Hatzakis Nikos S

Abstract excerpt

Bulk assays of SARS-CoV-2 entry obscure individual virions and conflate binding with internalization. We developed a quantitative single-particle imaging assay that classifies fluorescent virus-like particles (VLPs) as surface, crossing, or internal on HEK293T-ACE2 cells, separating binding from internalization. Comparing G614 and Omicron BA.5 S protein variants, G614 showed higher binding and a larger...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42606068
DOI: 10.1021/acsabm.6c00883

Genes

ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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