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Dissecting the Cell Entry Pathway of Dengue Virus by Single-Particle Tracking in Living Cells

18 Dec 2008

Abstract excerpt

Dengue virus (DENV) is an enveloped RNA virus that causes the most common arthropod-borne infection worldwide. The mechanism by which DENV infects the host cell remains unclear. In this work, we used live-cell imaging and single-virus tracking to investigate the cell entry, endocytic trafficking, and fusion behavior of DENV. Simultaneous tracking of DENV particles and various endocytic markers revealed that DENV...

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PMID: 19096510
DOI: 10.1371/journal.ppat.1000244

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