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Article

Barrier-to-Design Codes for Organ-Targeted Nanomedicine: A Framework Linking Barrier Phenotypes to Nano-Bio Interface Design and Translational Validation.

International journal of nanomedicine - 1 Jan 2026

Li Chenqi, Lu Hongtao, Qu Yicui, Shi Wenjing, Gao Zhiyuan, Shen Hui, Gao Biao

Abstract excerpt

Organ-targeted nanomedicine is often defined by anatomical destination, yet delivery performance is determined by the biological barriers, disease-associated remodeling, and nano-bio interface interactions encountered before therapeutically relevant cells are reached. Whole-organ accumulation, tissue fluorescence, or bulk biodistribution can demonstrate tissue arrival, but stronger targeting claims require...

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PMID: 42604385
DOI: 10.2147/IJN.S635649
PMCID: PMC13477176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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