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Evolutionary Convergence on a Dihydrofolate Reductase Mutation Drives Trimethoprim-Sulfamethoxazole Resistance in Burkholderia thailandensis.

ACS infectious diseases - 14 Aug 2026

Guillier Sophie, Lazennec-Schurdevin Christine, Mondange Lou, Sarilar Véronique, Marchandeau Mélissa, Lemoigne Chloé, Lamer Ombeline, Lescat Mathilde, Schmitt Emmanuelle, Mechulam Yves, Garrec Julian, Biot Fabrice

Abstract excerpt

Trimethoprim-sulfamethoxazole (SXT) remains central to melioidosis eradication therapy, yet the genetic basis of resistance evolution in Burkholderia pseudomallei is not fully defined. Using Burkholderia thailandensis as a biosafe surrogate, we subjected populations to stepwise in vitro evolution under increasing SXT concentrations. Whole-genome sequencing revealed rapid population diversification followed by...

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PMID: 42599400
DOI: 10.1021/acsinfecdis.5c01132
PMCID: PMC13488448

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DHFR

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