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Article

The importance of dopamine levels and single-nucleotide polymorphism within COMT, DRD1 and DRD2 genes in obstructive sleep apnoea.

Annals of medicine - 1 Dec 2025

Smardz Joanna, Martynowicz Helena, Dratwa-Kuzmin Marta, Wojakowska Anna, Gac Pawel, Bogunia-Kubik Katarzyna, Wieckiewicz Mieszko

Abstract excerpt

BACKGROUND: Obstructive sleep apnoea (OSA) is a prevalent sleep disorder that contributes to serious cardiovascular comorbidities. While the mechanical aspects of OSA are well-studied, its neurobiological underpinnings remain underexplored. In this study, we investigated the role of dopamine and its genetic modulators in OSA pathophysiology. PATIENTS AND METHODS: Serum dopamine levels were assessed in a cohort of...

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Identifiers

PMID: 40832754
DOI: 10.1080/07853890.2025.2548386
PMCID: PMC12369519

Genes

DRD2
COMT
DRD1

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