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Article

Understanding CD8+ T‐cell responses toward the native and alternate HLA‐A∗02:01‐restricted WT1 epitope

1 Mar 2017

Abstract excerpt

The Wilms’ tumor 1 (WT1) antigen is expressed in solid and hematological malignancies, but not healthy tissues, making it a promising target for cancer immunotherapies. Immunodominant WT1 epitopes, the native HLA‐A2/WT1126‐134 (RMFPNAPYL) (HLA‐A2/RMFPNAPYL epitope (WT1A)) and its modified variant YMFPNAPYL (HLA‐A2/YMFPNAPYL epitope (WT1B)), can induce WT1‐specific CD8+ T cells, although WT1B is more stably bound...

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PMID: 28435676
DOI: 10.1038/cti.2017.4

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