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Article

Genomic, Trop-2, and Immune Profiles of Carcinomatous and Sarcomatous Components in Ovarian Carcinosarcoma.

Cancer reports (Hoboken, N.J.) - 1 Aug 2026

Sakamaki Tomomi, Chiyoda Tatsuyuki, Nakamura Kohei, Takamatsu Reika, Kawano Ryutaro, Ochiai Daisuke, Jisaka Mitsuyo, Takahashi Mio, Yoshimura Takuma, Kimura Yumiko, Oki Shinya, Sakai Kensuke, Yoshihama Tomoko, Nishihara Hiroshi, Yamagami Wataru

Abstract excerpt

BACKGROUND: Ovarian carcinosarcoma (OCS) is a rare, aggressive tumor composed of both carcinomatous and sarcomatous components, typically associated with poor prognosis. Due to its rarity, the molecular characteristics, immune microenvironment, and optimal treatment of OCS remain unclear. This study aimed to characterize the genomic profiles, Trop-2 expression, and immune microenvironment of the carcinomatous and...

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Source

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Identifiers

PMID: 42598867
DOI: 10.1002/cnr2.70659
PMCID: PMC13474323

Genes

CCND1
CCNE1
ERBB2
GNAS
PRKCI
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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