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Article

Immunogenomic landscape of gynecologic carcinosarcoma.

Gynecologic oncology - 1 Feb 2021

Gotoh Osamu, Kiyotani Kazuma, Chiba Tomohiro, Sugiyama Yuko, Takazawa Yutaka, Nemoto Kensaku, Kato Kazuyoshi, Tanaka Norio, Nomura Hidetaka, Hasegawa Kosei, Fujiwara Keiichi, Takamatsu Shiro, Matsumura Noriomi, Noda Tetsuo, Mori Seiichi

Abstract excerpt

OBJECTIVE: Carcinosarcoma (CS) of the uterus or ovary is a rare, biphasic tumor comprising epithelial and mesenchymal elements, and exhibits more aggressive clinical features than its carcinoma counterpart. Four molecular subtypes of CS were recently established based on genomic aberration profiles (POLE, MSI, CNH, and CNL) and shown to be associated with multiple clinicopathological parameters, including patient...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33298310
DOI: 10.1016/j.ygyno.2020.11.030

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