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Article

Identification of a Post-translational Modification with Ribitol-Phosphate and Its Defect in Muscular Dystrophy.

Cell reports - 8 Mar 2016

Kanagawa Motoi, Kobayashi Kazuhiro, Tajiri Michiko, Manya Hiroshi, Kuga Atsushi, Yamaguchi Yoshiki, Akasaka-Manya Keiko, Furukawa Jun-Ichi, Mizuno Mamoru, Kawakami Hiroko, Shinohara Yasuro, Wada Yoshinao, Endo Tamao, Toda Tatsushi

Abstract excerpt

Glycosylation is an essential post-translational modification that underlies many biological processes and diseases. α-dystroglycan (α-DG) is a receptor for matrix and synaptic proteins that causes muscular dystrophy and lissencephaly upon its abnormal glycosylation (α-dystroglycanopathies). Here we identify the glycan unit ribitol 5-phosphate (Rbo5P), a phosphoric ester of pentose alcohol, in α-DG. Rbo5P forms a...

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Identifiers

PMID: 26923585
DOI: 10.1016/j.celrep.2016.02.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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