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DDX41 germline variants causing donor cell leukemia indicate a need for further genetic workup in the context of hematopoietic stem cell transplantation

10 May 2023

Abstract excerpt

Hematopoietic stem cell transplantation (HSCT) represents the standard treatment for patients with high or intermediate-2 risk (IPSS classification) myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) with intermediate or unfavorable risk (ELN classification) [ 1 ]. Despite recent progress in both induction treatment as well as conditioning regimens before transplantation and immunosuppression...

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PMID: 37160870
DOI: 10.1038/s41408-023-00846-2

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