[Management of genetic predisposition to hematologic malignancies in patients undergoing allogeneic hematopoietic cell transplantation (HCT): Guidelines from the SFGM-TC].

doi:10.1016/j.bulcan.2022.09.002

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Article

[Management of genetic predisposition to hematologic malignancies in patients undergoing allogeneic hematopoietic cell transplantation (HCT): Guidelines from the SFGM-TC].

Bulletin du cancer - 1 Feb 2023

Coiteux Valérie, Fenwarth Laurène, Duployez Nicolas, Ainaoui Malika, Borel Cécile, Polomeni Alice, Yakoub-Agha Ibrahim, Chalandon Yves

Abstract excerpt

The advent of new technologies has made it possible to identify genetic predispositions to myelodysplastic syndromes (MDS) and acute leukemias (AL) more frequently. The most frequent and best characterized at present are mutations in CEBPA, RUNX1, GATA2, ETV6 and DDX41 and, either in the presence of one of these mutations with a high allelic frequency, or in the case of a personal or family history suggestive of...

Topics

Humans
Genetic Predisposition to Disease
Hematologic Neoplasms
Hematopoietic Stem Cell Transplantation
Leukemia
Hematologic Diseases
Transplantation Conditioning

Source

Open in PubMed

Identifiers

PMID: 36307324
DOI: 10.1016/j.bulcan.2022.09.002

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