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Article

RAS Inhibitor RMC-7977 Blocks Vascular Overgrowth of NRASQ61R Mutant Endothelial Cells.

Journal of cellular and molecular medicine - 1 Aug 2026

Alharbi Sara, Merkle Svatava, Pastura Patricia, McDaniel C Griffin, Zaky George S, Waters Andrew M, Le Cras Timothy D

Abstract excerpt

RAS mutations occur in patients with several types of vascular anomalies, but effective treatments remain limited. To address this need, we evaluated the RAS (ON) multi-selective inhibitor RMC-7977 in human endothelial cells (ECs) expressing the NRASQ61R mutation found in kaposiform lymphangiomatosis (KLA). RMC-7977 was evaluated using in vitro and in vivo models. Doxycycline-inducible NRASWT and NRASQ61R human...

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PMID: 42576614
DOI: 10.1111/jcmm.71316
PMCID: PMC13458280

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ANG

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