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Article

NRASQ61R mutation drives elevated angiopoietin-2 expression in human endothelial cells and a genetic mouse model.

Pediatric blood & cancer - 1 Jul 2024

Pastura Patricia, McDaniel C Griffin, Alharbi Sara, Fox Dermot, Coleman Bethany, Malik Punam, Adams Denise M, Le Cras Timothy D

Abstract excerpt

BACKGROUND: Angiopoietin-2 (Ang-2) is increased in the blood of patients with kaposiform lymphangiomatosis (KLA) and kaposiform hemangioendothelioma (KHE). While the genetic causes of KHE are not clear, a somatic activating NRASQ61R mutation has been found in the lesions of KLA patients. PROCEDURE: Our study tested the hypothesis that the NRASQ61R mutation drives elevated Ang-2 expression in endothelial cells....

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Identifiers

PMID: 38711167
DOI: 10.1002/pbc.31032
PMCID: PMC11116044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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