Article
NRASQ61R mutation in human endothelial cells causes vascular malformations.
Angiogenesis - 1 Aug 2022
Boscolo Elisa, Pastura Patricia, Schrenk Sandra, Goines Jillian, Kang Rachael, Pillis Devin, Malik Punam, Le Cras Timothy D
Abstract excerpt
Somatic mutations in NRAS drive the pathogenesis of melanoma and other cancers but their role in vascular anomalies and specifically human endothelial cells is unclear. The goals of this study were to determine whether the somatic-activating NRASQ61R mutation in human endothelial cells induces abnormal angiogenesis and to develop in vitro and in vivo models to identify disease-causing pathways and test...
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