mTOR inhibition augments antitumor immune effector response by reprogramming the TP53-mutant, immune-cold HNSCC tumor microenvironment.

doi:10.1016/j.neo.2026.101350

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Article

mTOR inhibition augments antitumor immune effector response by reprogramming the TP53-mutant, immune-cold HNSCC tumor microenvironment.

Neoplasia (New York, N.Y.) - 1 Oct 2026

Nath Priyatosh, Khandelwal Alok, Li Chun, Moore-Medlin Tara, Vasudevan Srivatsa Surya, Alvarez Victor Albornoz, Franco Omar E, Gutkind J Silvio, Nathan Cherie-Ann O

Abstract excerpt

Resistance to immunotherapy remains a major clinical challenge in TP53-mutant head and neck squamous cell carcinoma (HNSCC), a disease subset characterized by immune exclusion, high recurrence, and poor outcomes. Given the constitutive activation of PI3K/AKT/mTOR signaling in TP53-mutant HNSCC and its role in disease progression, we investigated whether the mTOR inhibition (mTORi) could overcome immune resistance...

Read the complete abstract on PubMed

Topics

Tumor Microenvironment
Animals
Tumor Suppressor Protein p53
Humans
MTOR Inhibitors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mice

TOR Serine-Threonine Kinases

Mutation

Cell Line, Tumor

Everolimus

Squamous Cell Carcinoma of Head and Neck

Signal Transduction

Head and Neck Neoplasms

Disease Models, Animal

Lymphocytes, Tumor-Infiltrating

Source

Open in PubMed Open full text

Identifiers

PMID: 42570420
DOI: 10.1016/j.neo.2026.101350
PMCID: PMC13476742

Genes

TP53
CXCL10
TNF
VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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