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Host genetics influences HIV reservoir persistence, treatment outcomes and CCR5 expression in patients on long-term antiretroviral therapy in Ghana.

Frontiers in immunology - 1 Jan 2026

Appiah Peter Kwabena, Bonney Evelyn Yayra, Obirikorang Christian, Aboagye James Odame, Hanson Mildred Egyirba, Agomuo Samuel Kwame Sopuruchi, Effah Alfred, Annani-Akollor Max Efui, Kyei George Boateng

Abstract excerpt

Objective: This study investigated influence of cysteine-cysteine chemokines (CCR5, CCR5-59029A/G, CCR2), and stoma cell derived factor 1 (SDF1); as AIDS restriction genes (ARGs), on treatment outcomes among people with HIV (PWH) on long term antiretroviral therapy (ART) in Ghana. Methods: This cross-sectional study was conducted among 167 PWH and receiving ART in Accra, Ghana. Genomic DNA from PBMCs was used to...

Topics

Humans
Receptors, CCR5
HIV Infections
Ghana
Male
Female
Cross-Sectional Studies
Adult
HIV-1
Genotype
Treatment Outcome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Viral Load

Middle Aged

Chemokine CXCL12

Antiretroviral Therapy, Highly Active

Source

Open in PubMed Open full text

Identifiers

PMID: 42559043
DOI: 10.3389/fimmu.2026.1885690
PMCID: PMC13438377

Genes

CCR5
CCR2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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