Article
FYN, a Novel Target of Fragile X Mental Retardation Protein, Potentially Underlies ERK1/2 Hyperactivation in Fragile X Syndrome.
Molecular neurobiology - 5 Aug 2026
Huang Wen, Jiang Lin, Zhu YanPing, Duan Ranhui, Xue Jin, Xia Qiuping
Abstract excerpt
BACKGROUND: Fragile X syndrome (FXS), the most common inherited form of intellectual disability and the leading monogenic cause of autism, results from the loss of the fragile X mental retardation protein (FMRP). Dysregulated translation of FMRP target mRNAs is believed to underlie the aberrant synaptic plasticity observed in FXS. Identification of these targets is critical for elucidating disease mechanisms and...
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