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Article

FMRP targets distinct mRNA sequence elements to regulate protein expression.

Nature - 20 Dec 2012

Ascano Manuel, Mukherjee Neelanjan, Bandaru Pradeep, Miller Jason B, Nusbaum Jeffrey D, Corcoran David L, Langlois Christine, Munschauer Mathias, Dewell Scott, Hafner Markus, Williams Zev, Ohler Uwe, Tuschl Thomas

Abstract excerpt

Fragile X syndrome (FXS) is a multi-organ disease that leads to mental retardation, macro-orchidism in males and premature ovarian insufficiency in female carriers. FXS is also a prominent monogenic disease associated with autism spectrum disorders (ASDs). FXS is typically caused by the loss of fragile X mental retardation 1 (FMR1) expression, which codes for the RNA-binding protein FMRP. Here we report the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fragile X Mental Retardation Protein

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Share to Regulatory Sequences, Ribonucleic Acid

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Source

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Identifiers

PMID: 23235829
DOI: 10.1038/nature11737
PMCID: PMC3528815

Genes

FMR1
FXR1
FXR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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