Article
Genomic profiling of Mexican patients with B-cell precursor acute lymphoblastic leukemia reveals clinically significant somatic and potential germline variants.
The journal of pathology. Clinical research - 1 Sept 2026
Martínez Anaya Daniel, Juárez-Velázquez María Del Rocío, Juárez Figueroa Ulises, Dean Michael, Salas Labadía Consuelo, Valladares Coyotecatl Marian, Reyes León Adriana, López Santiago Norma, Juárez Villegas Luis, Zapata Tarrés Marta, Pérez-Vera Patricia
Abstract excerpt
B-cell precursor acute lymphoblastic leukemia (preB-ALL) is characterized by pathogenic variants currently used in precision oncology. However, the mutational landscape of Mexican children with preB-ALL has not yet been thoroughly explored and defined in terms of the clinical significance. We used a custom-designed next-generation sequencing exome panel, along with high-resolution chromosome microarrays and gene...
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