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Does Toxoplasma gondii infection have a causal impact on human psychopathology? A Mendelian randomization analysis.

PLoS pathogens - 1 Aug 2026

Pang Jinyong, Valente Matthew J, Kim Kami, Liu Xiaoming

Abstract excerpt

Toxoplasma gondii (T. gondii) is a prevalent zoonotic parasite that has been implicated in influencing human psychiatric disorders and risk-taking behaviors. Using genome-wide association study (GWAS) data, we selected 25 and 76 single-nucleotide polymorphisms as instrumental variables for anti-T. gondii IgG seropositivity and anti-T. gondii IgG levels, respectively, and conducted two-sample Mendelian...

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Genetic Predisposition to Disease
Genome-Wide Association Study
Mendelian Randomization Analysis
Mental Disorders
Polymorphism, Single Nucleotide

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PMID: 42550877
DOI: 10.1371/journal.ppat.1014312
PMCID: PMC13450837

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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