Association of chemokine and chemokine receptor gene variants with occurrence of multiple primary melanoma.

doi:10.1097/CMR.0000000000001128

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Article

Association of chemokine and chemokine receptor gene variants with occurrence of multiple primary melanoma.

Melanoma research - 1 Oct 2026

Orlow Irene, Luo Li, Autuori Isidora, Mina Isam, Mauguen Audrey, Edmiston Sharon N, Gallagher Richard P, Ollila David W, Lee Tim, Busam Klaus, Cust Anne E, Berwick Marianne, Begg Colin B, Kanetsky Peter A, Thomas Nancy E

Abstract excerpt

Chemokine and chemokine receptors (CKRs) regulate cell growth, tumor immunity, migration, angiogenesis, and metastasis. We evaluated associations of inherited chemokine/CKR variants with subsequent primary melanomas among patients with a previous melanoma. Our population-based cohort included 2458 incident single primary and 1205 multiple primary melanoma (MPM) cases. We examined 215 a priori candidate...

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