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Article

Causal associations of MICB, CTSA, and MMP9 proteins with oral cancer: Mendelian randomization study.

Scientific reports - 27 Oct 2024

Dong Bowen, Hua Jianlei, Ma Shengxuan, Wang Li, Xiao Haotian, Qiao Xianghe, Zhao Rui, Liu Yiming

Abstract excerpt

Oral cancer (ORCA) is the most prevalent histological subtype of oral malignancies in which immune modulation is relevant. The goal of this work was to employ Mendelian randomization (MR) to investigate the causal connection between the immune-related proteins MICB, CTSA, MMP9, and ORCA. The Open GWAS database of the Integrative Epidemiology Unit (IEU) was accessed to collect GWAS data for ORCA (ieu-b-4961), MICB...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39465349
DOI: 10.1038/s41598-024-77042-0
PMCID: PMC11514235

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