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Failing Fontan Following Total Cavopulmonary Connection: Extracardiac Biomarkers Reveal 2 Distinct Phenotypes With Divergent Clinical Courses.

Interdisciplinary cardiovascular and thoracic surgery - 3 Aug 2026

Matsubara Muneaki, Aldogan Havva, Schaeffer Thibault, Ruda Christina, Röhlig Christoph, Palm Jonas, Piber Nicole, Hager Alfred, Ewert Peter, Hörer Jürgen, Ono Masamichi

Abstract excerpt

OBJECTIVES: Failing Fontan is an increasingly recognized complication after total cavopulmonary connection (TCPC), yet longitudinal biomarker data remain scarce. We aimed to characterize the incidence, biomarker trajectories, and prognostic determinants of failing Fontan. METHODS: All patients who underwent primary TCPC (n = 650) or conversion to TCPC (n = 19) at our centre between 1994 and 2022 were reviewed....

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Biomarkers
Heart Defects, Congenital
Heart Failure
Lymphocyte Count
Natriuretic Peptide, Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peptide Fragments

Treatment Failure

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Identifiers

PMID: 42530872
DOI: 10.1093/icvts/ivag213
PMCID: PMC13496394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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