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Article

Pediatric heart failure in the era of cardio-immunology: inflammatory-immune context phenotypes, diagnosis, and targeted management.

Frontiers in immunology - 1 Jan 2026

Li Danna, Yao Dezhen

Abstract excerpt

Pediatric heart failure (PHF) is a heterogeneous syndrome whose etiologies, developmental biology, and clinical trajectories differ fundamentally from adult heart failure. Beyond age-specific hemodynamics and neurohormonal activation, inflammatory and immune programs can serve as primary drivers (e.g., myocarditis, multisystem inflammatory syndrome in children [MIS-C]) or as potent amplifiers of decompensation...

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Identifiers

PMID: 42088493
DOI: 10.3389/fimmu.2026.1776897
PMCID: PMC13136529

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