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Article

GPR19 Drives Cell Cycle Progression via ERK-Dependent FOXM1 Activation in p53-Mutant Breast Cancer.

Frontiers in bioscience (Landmark edition) - 24 Jul 2026

Qiu Jihan, Tian Cheng, Li Hanzhi, Gao Sumei, Yang Chengcheng, Luo Qiuyan, Liu Yang, He Kuan, Li Kang, Peng Yang, Yu Haochen, Tang Lingfeng, Liu Shengchun

Abstract excerpt

BACKGROUND: G protein-coupled receptor 19 (GPR19) is an orphan G protein-coupled receptor with emerging relevance in cancer; however, its role in breast cancer remains poorly understood. Given the high frequency of tumor protein p53 (TP53) alterations in aggressive breast cancer, particularly triple-negative breast cancer (TNBC), we investigated the clinical significance, biological function, and molecular...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Signal-Regulated MAP Kinases

Share to Gene Expression Regulation, Neoplastic

Share to Mice, Nude

Share to Receptors, G-Protein-Coupled

Share to Triple Negative Breast Neoplasms

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 42530251
DOI: 10.31083/FBL52064

Genes

GPR19
TP53
FOXM1
CCNB1
PLK1
MB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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