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Article

Metabolomics Effects of Folding Correction in Retinitis Pigmentosa Rhodopsin Mutant P23A.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 15 Aug 2026

Murthy Meghana Hosahalli Shivananda, Staggs-Sandy Hannah, Jasbi Paniz, Reeves Philip J, Klein-Seetharaman Judith

Abstract excerpt

Retinitis pigmentosa (RP) is a hereditary retinal degeneration disorder often caused by mutations in the rhodopsin gene, leading to photoreceptor death and vision loss. While structural misfolding of rhodopsin is a known contributor to disease pathology, the mechanisms of its cellular and in particular metabolic consequences are poorly understood. To study the direct effects of rhodopsin misfolding and structural...

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Identifiers

PMID: 42522759
DOI: 10.1096/fj.202505024R
PMCID: PMC13417540

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GC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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