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Article

Proteomic survey reveals altered energetic patterns and metabolic failure prior to retinal degeneration.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 Feb 2014

Griciuc Ana, Roux Michel J, Merl Juliane, Giangrande Angela, Hauck Stefanie M, Aron Liviu, Ueffing Marius

Abstract excerpt

Inherited mutations that lead to misfolding of the visual pigment rhodopsin (Rho) are a prominent cause of photoreceptor neuron (PN) degeneration and blindness. How Rho proteotoxic stress progressively impairs PN viability remains unknown. To identify the pathways that mediate Rho toxicity in PNs, we performed a comprehensive proteomic profiling of retinas from Drosophila transgenics expressing Rh1(P37H), the...

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Source

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Identifiers

PMID: 24553922
DOI: 10.1523/JNEUROSCI.2982-13.2014
PMCID: PMC6608515

Genes

TRAF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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