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From Molecular Classification to Hereditary Cancer Syndrome Identification in Endometrial Cancer.

Genes - 14 Jul 2026

Libera Laura, Carnevali Ileana, Facchi Sofia, Sahnane Nora, Travaglino Antonio, La Rosa Stefano, Tibiletti Maria Grazia

Abstract excerpt

Background: Endometrial carcinoma (EC) is one of the most common gynaecological malignancies, with a steadily increasing incidence worldwide. In 2013, a novel molecular classification of ECs enabled patient stratification into four groups with important clinical management implications: (1) DNA Polymerase Epsilon (POLE)-mutated, (2) microsatellite instability-high (MSI-H/dMMR) hypermutated, (3) tumours with low...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42510841
DOI: 10.3390/genes17070801
PMCID: PMC13410080

Genes

POLE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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