Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel Insights into Immune Cell Function in Type 2 Diabetes Mediated by Gut Microbiota: A Two-Sample Mendelian Randomization Study.

Endocrine, metabolic & immune disorders drug targets - 1 Jan 2026

Zhou Zeyu, Liu Zenghui, Wang Siming, Xu Wenting, Xue Qian, Wu Aoni, Sun Qiyu

Abstract excerpt

INTRODUCTION: The role of immune cells in type 2 diabetes mellitus (T2DM) development is well-studied, but their interactions with the gut microbiota and the mediating role in this process remain unclear. METHODS: We analyzed 731 immune cell phenotypes (3,757 Europeans), 473 gut microbiota traits (5,959 Finns), and T2DM data (over 400,000 Finns). Mendelian randomization (MR) was based on three assumptions: the...

Read the complete abstract on PubMed

Topics

Diabetes Mellitus, Type 2
Humans
Mendelian Randomization Analysis
Gastrointestinal Microbiome
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genome-Wide Association Study

Risk Factors

Finland

Source

Identifiers

PMID: 41620922
DOI: 10.2174/0118715303415778251119053933

Genes

CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel Insights into Immune Cell Function in Type 2 Diabetes Mediated by Gut Microbiota: A Two-Sample Mendelian Randomization Study.PMID 41620922Read ↗

The causal relationship between gut microbiota and type 2 diabetes: a two-sample Mendelian randomized studySemantic proximity Read ↗

Gut microbiota and type 1 diabetes: a two-sample bidirectional Mendelian randomization studySemantic proximity Read ↗

Type 2 diabetes and Inflammatory Bowel Disease: A Bidirectional Two-sample Mendelian Randomization StudySemantic proximity Read ↗

Causal relationships between the gut microbiota, immune cells, and diabetic kidney disease: a Mendelian randomization and mediation analysis.Semantic proximity Read ↗

Gut Microbiota and Type 2 Diabetes: Genetic Associations, Biological Mechanisms, Drug Repurposing, and Diagnostic Modeling.Semantic proximity Read ↗

Causal Relationship Between Gut Microbiota and Autoimmune Diseases: A Two-Sample Mendelian Randomization Study.Semantic proximity Read ↗

Disentangling the Immune Cell-Mediated Causal Effects of Gut Microbiota on Inflammatory Bowel Disease via Mendelian RandomizationSemantic proximity Read ↗

Causal relationship between gut microbiota and diabetic complications: a two- sample Mendelian Randomization studySemantic proximity Read ↗

Causal Relationship between Peripheral Immune Cell Counts and Inflammatory Bowel Diseases: A Bi-directional Two-sample Mendelian Randomization StudySemantic proximity Read ↗

Genetically predicted immune cells mediate the association between gut microbiota and autoimmune liver diseasesSemantic proximity Read ↗

Causal relationship between gut microbiota and diabetes based on Mendelian randomization.Semantic proximity Read ↗

Genetic associations between gut microbiota and type 2 diabetes mediated by plasma metabolites: a Mendelian randomization study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.