Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

One-carbon metabolism and chemotherapy-induced toxicities in patients with stage II-III colorectal cancer: a prospective cohort study.

The American journal of clinical nutrition - 1 Sept 2026

Zwart Nienke Rk, van Duijnhoven Fränzel Jb, Wesselink Evertine, Lubberman Floor Je, Ulrich Cornelia M, McKay Jill A, van Halteren Henk K, McCann Adrian, Ueland Per Magne, Kampman Ellen, Kok Dieuwertje E

Abstract excerpt

BACKGROUND: One-carbon metabolism (OCM) is a target of the chemotherapeutic agent capecitabine. OBJECTIVES: We investigated OCM biomarker concentrations in relation to capecitabine-induced toxicities in patients with stage II-III colorectal cancer. METHODS: Within a prospective cohort, 297 patients receiving adjuvant capecitabine-based chemotherapy were included. Pretreatment plasma concentrations of the OCM...

Read the complete abstract on PubMed

Topics

Humans
Colorectal Neoplasms
Capecitabine
Methylenetetrahydrofolate Reductase (NADPH2)
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Prospective Studies

Male

Folic Acid

Middle Aged

Aged

Vitamin B 6

Vitamin B 12

Biomarkers

Riboflavin

Carbon

Genotype

Antimetabolites, Antineoplastic

Homocysteine

Source

Identifiers

PMID: 42508575
DOI: 10.1016/j.ajcnut.2026.101457

Genes

OCM
MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 26 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

One-carbon metabolism and chemotherapy-induced toxicities in patients with stage II-III colorectal cancer: a prospective cohort study.PMID 42508575Read ↗

ONE-CARBON METABOLISM AND CHEMOTHERAPY-INDUCED TOXICITIES IN PATIENTS WITH STAGE II-III COLORECTAL CANCERSemantic proximity Read ↗

Pathway analysis of genetic variants in folate‐mediated one‐carbon metabolism‐related genes and survival in a prospectively followed cohort of colorectal cancer patientsSemantic proximity Read ↗

Folate-mediated one-carbon metabolism genes and interactions with nutritional factors on colorectal cancer risk: Women's Health Initiative Observational Study.Semantic proximity Read ↗

Oxaliplatin, irinotecan and capecitabine as first-line therapy in metastatic colorectal cancer (mCRC): a dose-finding study and pharmacogenomic analysis.Semantic proximity Read ↗

MTHFR polymorphisms and capecitabine-induced toxicity in patients with metastatic colorectal cancer.Semantic proximity Read ↗

Variants of carboxylesterase 1 have no impact on capecitabine pharmacokinetics and toxicity in capecitabine plus oxaliplatin treated-colorectal cancer patients.Semantic proximity Read ↗

Components of One-carbon Metabolism Other than Folate and Colorectal Cancer Risk.Semantic proximity Read ↗

Evaluation of 5-fluorouracil degradation rate and Pharmacogenetic profiling to predict toxicity following adjuvant Capecitabine.Semantic proximity Read ↗

Carboxylesterase 1 polymorphisms are associated with clinical outcomes in gastroenteric cancer patients treated with capecitabine.Semantic proximity Read ↗

Gene-diet-interactions in folate-mediated one-carbon metabolism modify colon cancer risk.Semantic proximity Read ↗

The role of pharmacogenetics in capecitabine efficacy and toxicity.Semantic proximity Read ↗

Effect of DPYD, MTHFR, ABCB1, XRCC1, ERCC1 and GSTP1 on chemotherapy related toxicity in colorectal carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.