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Article

The role of pharmacogenetics in capecitabine efficacy and toxicity.

Cancer treatment reviews - 1 Nov 2016

Lam S W, Guchelaar H J, Boven E

Abstract excerpt

Capecitabine is an oral prodrug of 5-fluorouracil (5-FU) and approved for treatment of various malignancies. Hereditary genetic variants may affect a drug's pharmacokinetics or pharmacodynamics and account for differences in treatment response and adverse events among patients. In this review we present the current knowledge on genetic variants, commonly single-nucleotide polymorphisms (SNPs), tested in cohorts...

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Topics

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Share to Antimetabolites, Antineoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Dihydrouracil Dehydrogenase (NADP)

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Source

Identifiers

PMID: 27569869
DOI: 10.1016/j.ctrv.2016.08.001

Genes

DPYD
CDA
TYMS
CES2
MTHFR
TYMP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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