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Cell-type-specific m1A dynamics are associated with microglial phenotypic transition and neuronal metabolic adaptation during spinal cord injury.

PLoS computational biology - 1 Jul 2026

Zhang Chi, Li Shaolong, Jiang Ruizhi, Duan Heng, Li Chuang, Qi Enlin, Wu Mingxin, Li Xueying, Feng Shiqing, Zhou Hengxing

Abstract excerpt

m1A (N1-methyladenosine) is an important epigenetic mechanism that regulates the onset and progression of many diseases, including spinal cord injury (SCI). To investigate the overall changes in m1A following SCI, we analyzed transcriptomic sequencing data from SCI samples and assigned m1A scores based on the levels of m1A regulatory factors. In this study, the m1A score is an inferred proxy calculated from the...

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Adaptation, Physiological
Adenosine
Computational Biology
Epigenesis, Genetic
Microglia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spinal Cord Injuries

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PMID: 42497212
DOI: 10.1371/journal.pcbi.1014573
PMCID: PMC13423174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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