Dynamic 3D imaging system detects vasculogenic mimicry and screens inhibitors in EGFR-mutant lung cancer.

doi:10.1016/j.trsl.2026.07.010

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Article

Dynamic 3D imaging system detects vasculogenic mimicry and screens inhibitors in EGFR-mutant lung cancer.

Translational research : the journal of laboratory and clinical medicine - 1 Oct 2026

Lee Chun-Hui, Wu Shang-Yin, Chung Wei-Pang, Yeh Yu-Min, Wang Hsueh-Chun, Hong Tse-Ming, Chen Helen H W, Chiu Wen-Tai, Su Wu-Chou

Abstract excerpt

Vasculogenic mimicry (VM), wherein tumor cells form vessel-like structures independent of endothelial cells, drives metastasis and therapeutic resistance. Current in vitro VM research relies on conventional two-dimensional imaging, which fails to capture complex three-dimensional VM architecture, limiting anti-VM therapeutic development. We established a novel dynamic 3D imaging platform utilizing light sheet...

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PMID: 42492805
DOI: 10.1016/j.trsl.2026.07.010

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EGFR

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