Article
Association between single-nucleotide polymorphisms in endochondral development-related genes and 3D phenotypic variation of the cranial base.
Head & face medicine - 21 Jul 2026
Marañón-Vásquez Guido Artemio, Tirre de Souza Araújo Mônica, Carlos de Oliveira Ruellas Antônio, Matsumoto Mírian Aiko Nakane, Chávez Alejandro David Avalos, Figueiredo Marcio, de Oliveira Fernandes Thaís, Antunes Lívia Azeredo Alves, Lagravère Vich Manuel, Scariot Rafaela, Flores-Mir Carlos, Kirschneck Christian, Dos Santos Antunes Leonardo, Küchler Erika Calvano
Abstract excerpt
BACKGROUND: This study aimed to evaluate the association between single nucleotide polymorphisms (SNPs) in endochondral development-related genes and cranial base 3D phenotypes. METHODS: CBCT scans and the genomic DNA of 118 individuals were evaluated (age range: 15-66 years; 82 females). Data from eleven 3D landmarks identified at the cranial base were subjected to geometric morphometric analysis, including...
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