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Article

Correlation of RUNX2 Variants With Craniofacial-Dental Phenotypes in Cleidocranial Dysplasia.

Clinical and experimental dental research - 1 Apr 2026

Chantarawaratit Pintu-On, Thaweesapphithak Sermporn, Pittayapat Pisha, Porntaveetus Thantrira

Abstract excerpt

OBJECTIVES: Cleidocranial dysplasia (CCD) is a rare RUNX2-related skeletal disorder characterized by craniofacial anomalies and skeletal Class III malocclusion. However, the relationship between RUNX2 variant type and phenotype severity remains unclear. This study aimed to evaluate the association between RUNX2 variant types and the severity of skeletal Class III malocclusion and dental anomalies in CCD. MATERIAL...

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Source

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Identifiers

PMID: 41995300
DOI: 10.1002/cre2.70351
PMCID: PMC13088869

Genes

RUNX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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