Article
Candidate gene analyses of 3-dimensional dentoalveolar phenotypes in subjects with malocclusion.
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics - 1 Mar 2017
Weaver Cole A, Miller Steven F, da Fontoura Clarissa S G, Wehby George L, Amendt Brad A, Holton Nathan E, Allareddy Veeratrishul, Southard Thomas E, Moreno Uribe Lina M
Abstract excerpt
INTRODUCTION: Genetic studies of malocclusion etiology have identified 4 deleterious mutations in genes DUSP6,ARHGAP21, FGF23, and ADAMTS1 in familial Class III cases. Although these variants may have large impacts on Class III phenotypic expression, their low frequency (<1%) makes them unlikely to explain most malocclusions. Thus, much of the genetic variation underlying the dentofacial phenotypic variation...
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