Genetic liability for morning chronotype interacts with childhood trauma to predict depressive symptoms in women.

Abstract excerpt

INTRODUCTION: Depression is a highly heterogeneous disorder with a similarly heterogeneous neurobiological background. Understanding separate depressive phenotypes, driven by distinct aetiological pathways like early trauma and neurobiological contributors, can improve treatment. Furthermore, sex differences must be considered, as both the development and treatment of depression may be sex-specific. We aimed to...

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• Adverse Childhood Experiences
• Circadian Rhythm
• Depression
• Genetic Predisposition to Disease
• Genetic Risk Score