Article
The implications of gene-environment interactions in depression: will cause inform cure?
Molecular psychiatry - 1 Dec 2008
Uher R
Abstract excerpt
In a number of human diseases, including depression, interactions between genetic and environmental factors have been identified in the absence of direct genotype-disorder associations. The lack of genes with major direct pathogenic effect suggests that genotype-specific vulnerabilities are balanced by adaptive advantages and implies aetiological heterogeneity. A model of depression is proposed that incorporates...
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