Association of cardiovascular-kidney-metabolic syndrome with risk of hip/knee osteoarthritis: A prospective cohort study.

doi:10.1016/j.maturitas.2026.109056

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Association of cardiovascular-kidney-metabolic syndrome with risk of hip/knee osteoarthritis: A prospective cohort study.

Maturitas - 1 Sept 2026

Ma Zheng, Zhang Yixiao, Li Liuxin, Zheng Gang, Yang Honghao, Zhang Ruiyao, Li Yuqian, Wang Wenxu, Ji Chao, Xia Yang, Zhao Yuhong

Abstract excerpt

BACKGROUND: Cardiovascular-kidney-metabolic syndrome reflects the interplay of metabolic, renal, and cardiovascular dysfunction and is linked to adverse health outcomes. Its association with osteoarthritis remains unclear. METHODS: This prospective cohort study included 256,364 UK Biobank participants free of osteoarthritis at baseline. Cardiovascular-kidney-metabolic syndrome was classified into five stages...

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PMID: 42470749
DOI: 10.1016/j.maturitas.2026.109056

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