Article
The SEMA7AN559Y mutation facilitates the development of metabolic dysfunction-associated steatotic liver disease by inducing ROS/NLRP3-mediated hepatic cell pyroptosis.
Metabolism: clinical and experimental - 1 Mar 2026
Zhang Xiaoxun, Lei Jiaxin, Zhao Nan, Zhu Zhixian, Ding Jingjing, Pan Qiong, Liu Wen-Yue, Jin Xiao-Zhi, Lian Li-You, Zheng Ming-Hua, Chai Jin
Abstract excerpt
BACKGROUND AND AIMS: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common chronic liver condition that can result in significant liver damage. This study aimed to evaluate the effects of the SEMA7AN559Y mutation on MASLD progression and to explore potential therapeutic targets. METHODS: To examine the impact of the SEMA7AN559Y mutation on MASLD progression, we generated Sema7aN557Y (equal...
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