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Next-generation sequencing-based characterization of BRCA1/2 variants across multiple tumor types in Vietnamese patients.

BMC cancer - 17 Jul 2026

Nguyen Hong-Thanh, Vu Minh-Duc, Nguyen Dinh-Dung, Dinh Phuong-Nhung, Hoang Van-Quy, Bui Linh-Trang Ngoc, Nguyen Dinh-Tuan, Do Phuoc-Huy, Tong Thi-Oanh, Nguyen Van-Hung, Han Thu-Huong Thi, Ha Sy-Tung, Do Huy-Duong, Ly Thanh-Ha Thi, Nguyen Viet-Nhan

Abstract excerpt

BACKGROUND: Mutations in the BRCA1 and BRCA2 genes play a pivotal role in the pathogenesis of breast, ovarian, prostate, pancreatic, and several other cancers. Identification of these mutations is crucial for selecting patients eligible for targeted therapy. In Vietnam, large-scale data on BRCA1/2 mutation prevalence and clinical utility are limited. We aim to report the prevalence of BRCA1/2 mutations across...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42464142
DOI: 10.1186/s12885-026-16085-0
PMCID: PMC13377777

Genes

BRCA1
BRCA2
KIT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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