NCKX5, a natural regulator of human skin colour variation, regulates the expression of key pigment genes MC1R and alpha-MSH and alters cholesterol homeostasis in normal human melanocytes.

doi:10.1007/978-1-4614-4756-6_9

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

NCKX5, a natural regulator of human skin colour variation, regulates the expression of key pigment genes MC1R and alpha-MSH and alters cholesterol homeostasis in normal human melanocytes.

Advances in experimental medicine and biology - 1 Jan 2013

Wilson Stephen, Ginger Rebecca S, Dadd Tony, Gunn David, Lim Fei-Ling, Sawicka Magdalena, Sandel Melanie, Schnetkamp Paul P M, Green Martin R

Abstract excerpt

Natural human skin colour is determined both by environmental exposure to ultraviolet light and through inherited genetic variation in a very limited number of genes. Variation of a non-synonymous single-nucleotide polymorphism (nsSNP; rs1426654) in the gene (SLC24A5) encoding the NCKX5 protein is associated with differences in constitutive skin colour in South Asians. The nsSNP encodes the substitution of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-MSH

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptor, Melanocortin, Type 1

Share to Skin Pigmentation

Share to trans-Golgi Network

Source

Open in PubMed

Identifiers

PMID: 23224873
DOI: 10.1007/978-1-4614-4756-6_9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NCKX5, a natural regulator of human skin colour variation, regulates the expression of key pigment genes MC1R and alpha-MSH and alters cholesterol homeostasis in normal human melanocytes.PMID 23224873Read ↗

SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis.Semantic proximity Read ↗

The Role of SLC24A5 (NCKX5) in Human Skin Pigmentation: The Importance of Cation Transport Activity.Semantic proximity Read ↗

SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans.Semantic proximity Read ↗

A functional approach to understanding the role of NCKX5 in Xenopus pigmentation.Semantic proximity Read ↗

Molecular characterization of SLC24A5 variants and evaluation of Nitisinone treatment efficacy in a zebrafish model of OCA6.Semantic proximity Read ↗

Cellular localization of the K+ -dependent Na+ -Ca2+ exchanger NCKX5 and the role of the cytoplasmic loop in its distribution in pigmented cells.Semantic proximity Read ↗

A genome-wide genetic screen uncovers novel determinants of human pigmentationSemantic proximity Read ↗

A golden age of human pigmentation genetics.Semantic proximity Read ↗

A genome-wide genetic screen uncovers determinants of human pigmentationSemantic proximity Read ↗

Molecular genetics of human pigmentation diversity.Semantic proximity Read ↗

Loci associated with skin pigmentation identified in African populations.Semantic proximity Read ↗

The light skin allele of SLC24A5 in South Asians and Europeans shares identity by descent.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.