Article
SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans.
Science (New York, N.Y.) - 16 Dec 2005
Lamason Rebecca L, Mohideen Manzoor-Ali P K, Mest Jason R, Wong Andrew C, Norton Heather L, Aros Michele C, Jurynec Michael J, Mao Xianyun, Humphreville Vanessa R, Humbert Jasper E, Sinha Soniya, Moore Jessica L, Jagadeeswaran Pudur, Zhao Wei, Ning Gang, Makalowska Izabela, McKeigue Paul M, O'donnell David, Kittles Rick, Parra Esteban J, Mangini Nancy J, Grunwald David J, Shriver Mark D, Canfield Victor A, Cheng Keith C
Abstract excerpt
Lighter variations of pigmentation in humans are associated with diminished number, size, and density of melanosomes, the pigmented organelles of melanocytes. Here we show that zebrafish golden mutants share these melanosomal changes and that golden encodes a putative cation exchanger slc24a5 (nckx5) that localizes to an intracellular membrane, likely the melanosome or its precursor. The human ortholog is highly...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.