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Article

Alarming levels of fluoroquinolone resistance among MDR-TB patients in Poland: molecular and phenotypic analysis.

Frontiers in cellular and infection microbiology - 1 Jan 2026

Kozińska Monika, Głogowska Agnieszka, Minias Alina, Dziadek Jarosław, Augustynowicz-Kopeć Ewa

Abstract excerpt

Background: Fluoroquinolones (FQs) are a cornerstone of modern multidrug-resistant tuberculosis (MDR-TB) treatment, particularly within the WHO-recommended all-oral BPaLM regimen. The emergence of FQ-resistant Mycobacterium tuberculosis (MTB) poses a critical threat to these life-saving therapies. While the global proportion of FQ resistance among MDR/RR-TB cases is estimated at 19%, phenotypic and molecular data...

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PMID: 42459339
DOI: 10.3389/fcimb.2026.1881444
PMCID: PMC13368571

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