Article

Coordinated suppression of lectin complement pathway effectors and upregulation of SERPING1 defines a thrombo-inflammatory regulatory signature in cardiovascular disease

2026-05-11

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Cardiovascular disease (CVD), the leading global cause of death, is driven by thrombo-inflammatory processes. These involve oxidative stress, endothelial dysfunction, and innate immune dysregulation. The lectin complement pathway contributes to coagulation through thrombin-like activity and fibrin cross-linking, yet its transcriptional regulation under oxidati...

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Literature Corpus work: f4e6d581-704e-55e6-81dc-2a53f4ce0324
DOI: 10.21203/rs.3.rs-9553707/v1

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