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Article

xinguangA preliminary characterization of PI4K/PIPK alterations across solid tumors: an exploratory framework for prognostic and therapeutic stratification.

Cancer biology & therapy - 31 Dec 2026

Jie Yaqiong, Lu Zhongyu, Wang Xiaoxuan, Chen Dongsheng, Zhang Xing, Han Xinguang

Abstract excerpt

BACKGROUND: This study aimed to systematically characterize the genomic alteration landscape of phosphatidylinositol 4-kinase (PI4K) and phosphatidylinositol phosphate kinase (PIPK) family genes in solid tumors, assess the correlation of these alterations with patient clinical outcomes and the tumor immune microenvironment, and explore their potential as novel biomarkers or therapeutic targets. METHODS: A...

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Biomarkers, Tumor
Minor Histocompatibility Antigens
Mutation
Neoplasms
Phosphotransferases (Alcohol Group Acceptor)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Microenvironment

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Identifiers

PMID: 42445966
DOI: 10.1080/15384047.2026.2692173
PMCID: PMC13371475

Genes

PI4K2B
PIP4K2C

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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