Hemorrhage-coagulation immune phenotype is associated with CD163/HO-1-enriched heme-processing macrophage remodeling and predicts recurrence in colorectal cancer: a real-world retrospective cohort study.

Abstract excerpt

Background: Coagulation activation and tumor hemorrhage are common in colorectal cancer, but their combined immunological meaning remains incompletely defined. We developed a prespecified hemorrhage-coagulation immune phenotype (HCIP) integrating local hemorrhagic pathology and systemic coagulation activation, and evaluated its association with recurrence-free survival (RFS), CD163/HO-1-enriched immune...

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