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Article

Rule-derived preoperative inflammatory-lymphocyte recovery phenotype and pathological response in resected osteosarcoma: a retrospective cohort study.

Frontiers in immunology - 1 Jan 2026

Liu Yang, Huang Hua, Yang Ke, Gao Daxin, Hao Tian, Zhou Haiyu, Huang Yonghong

Abstract excerpt

Background: Pathological response after neoadjuvant chemotherapy is a key treatment milestone in osteosarcoma. We evaluated whether a rule-derived preoperative peripheral inflammatory-lymphocyte recovery phenotype constructed from routinely collected laboratory measurements was associated with poor pathological response. Methods: This single-center retrospective cohort included patients with osteosarcoma who...

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Topics

Humans
Osteosarcoma
Female
Retrospective Studies
Male
Neoadjuvant Therapy

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Lymphocytes

Phenotype

Bone Neoplasms

Adult

Adolescent

Young Adult

Treatment Outcome

Inflammation

Child

Source

Open in PubMed Open full text

Identifiers

PMID: 42769412
DOI: 10.3389/fimmu.2026.1925540
PMCID: PMC13590790

Genes

EFS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 16 Oct 2026.

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