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Article

Genetically Predicted 12,13-DiHOME Mediates the Association between TNF-Related Apoptosis-Inducing Ligand and Immune Thrombocytopenia.

Endocrine, metabolic & immune disorders drug targets - 1 Jan 2026

Jiang Chendong, Chen Yiwen, Liang Jun, Feng Yang, Gao Zhanyan, Sun Zhan, Wang Jie

Abstract excerpt

INTRODUCTION: The role of Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) has been highlighted in autoimmune and metabolic disorders. However, there is still an inadequate explanation of its causal relationship with primary immune thrombocytopenia (ITP). This study employed Mendelian Randomization (MR) to identify the potential causal associations among TRAIL, plasma metabolites, and ITP....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42444156
DOI: 10.2174/0118715303462239260413042004

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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